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by: N.J. Reinhoud
- September 7, 1995
Capillary electrophoresis (CE) is characterised by highly efficient separations in presence of a high electric field. The use of narrow bore capillaries provides an efficient way of dissipating the Joule heat. CE can be performed in several modes depending on the buffer system that is used. Switching between different modes is easy. Adding a chiral selector to the buffer enables enantiomer separations, adding a soluble gel enables the separation of macromolecules based on molecular mass. The poor detection sensitivity is the limiting factor in the applicability of CE in analytical methods. In this thesis several approaches are described of improving the loadability and the determination limits in CE.
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