 |
|
|
|
- 221-010
- Glutathione and other Disulfides
Glutathione (GSH) is a tripeptide composed of
glutamate, cysteine and glycine that has
numerous important functions in living cells.
GSH is involved in detoxification and serves as
antioxidant in the highly oxidizing environment
of the erythrocyte. The sulfhydryl of GSH can
reduce peroxides formed during oxygen transport.
The resulting oxidized GSH consists of two
molecules, di-glutathione (GSSG). The
measurement of GSH, GSSG, cysteine, cystine and
other thiols and disulfides in biological
samples is essential to determine the redox and
detoxification status of cells and tissue. The
analysis these thiols as well as the oxidised
free disulfides will be presented using an
ALEXYS system with electrochemical detector and
Dual Cell Control (DCC).
- 221-017
- Macrolide and Aminoglycoside Antibiotics
Analyser
A dedicated analyser for the analysis of
aminoglycosides such as Neomycin, Tobramycin,
Gentamicin, Lincomycin, Spectinomycin, Kanamycin
and Amikacin will be presented. The system is
ideally suited for the analysis of these
antibiotics in pharmaceutical formulations, and
bulk products including the identification and
quantification of their by-products and
impurities. Furthermore, almost any other type
of sample that needs to be analysed for the
presence of aminoglycosides antibiotics, i.e.,
dairy- and sea products, meat (cow, chicken)
etc., can be easily processed. Examples of
several validated assays will be presented.
- 221-018
- Azithromycin
Azithromycin is a semi-synthetic macrolide
antibiotic chemically related to erythromycin
and clarithromycin. It is effective against a
wide variety of bacteria organisms, such as
Hemophilus influenzae, Streptococcus pneumoniae,
Staphylococcus aureus, and many others.
Azithromycin is used to treat bacterial
infections such as bronchitis, pneumonia,
sexually transmitted diseases, and infections of
the ears, lungs, skin, and throat. The official
USP method has been applied for analysis of
pharmaceutical formulations, using an ALEXYS 100
LC-EC system with electrochemical detection.
Applicability for analysis of Clarithromycin,
Erythromycin, Roxithromycin, and Azaerythromycin
has been demonstrated as well.
- 221-019
- Resveratrol, Epicatechin, Quercetin and Other Polyphenols
Resveratrol, Epicatechin, Quercetin and other
Polyphenols in Wine and Food
Flavonoids are a group of naturally occurring
antioxidant compounds that are thought to have
therapeutic importance in cardiovascular disease
and as cancer preventive agents. Resveratrol,
quercetin, and other polyphenolic flavonoids are
not only found in wine, but also green tea,
chocolate, cocoa and several other food
products. A method is presented for the analysis
of epicatechin, epigallocatechin,
epigallocatechingallate, myricetin, quercetin,
keampferol and cis and trans resveratrol. An
ALEXYS gradient LC system with electrochemical
detection has been applied. Applicability of the
method has been demonstrated for the analysis of
wine, tea and chocolate.
|
|
|
 |
 |
|
|
